Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
Endothelial Cells as a Key Cell Type for Innate Immunity: A Focused Review on RIG-I Signaling Pathway선천성 면역을 위한 핵심 세포 유형으로서의 내피 세포: RIG-I 신호 전달 경로에 대한 집중 검토Review Published on 2022-07-052022-09-11 Journal: Frontiers in Immunology [Category] 치료법, [키워드] Activation anti-viral response Atherosclerosis Bacteria Bacterial bacterial and viral infections bloodstream cardiovascular disease cardiovascular diseases caused Cell cell type close contact contact with COVID-19 danger signals DDX58 demonstrated disorder disorders dsDNA dsRNA endothelial Endothelial cell endothelial cells Endothelial dysfunction Evidence expression function heterogeneous highlight host antiviral response immune immune functions immune surveillance Immunity Infectious disease Inflammation Inflammation. inhibited Innate Innate immunity interferons invading pathogen Ligand Like LPS macrophages microbial infection Panax notoginseng pathogen Pathogens PPARγ provided PRR recent receptor retinoic acid review RIG-I saponins shown signal signaling pathway Surveillance translational Type Vascular endothelium viral infection viral infections virus virus virus infection [DOI] 10.3389/fimmu.2022.951614 PMC 바로가기 [Article Type] Review
Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia중증 COVID-19 폐렴 노인 환자의 분자 및 세포 면역 특징Article Published on 2022-06-162022-09-12 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] activated activated macrophage age aging anti-RBD anti-S anti-viral response antibodies CD4 CD56 Cell cellular central memory circulating Clinical outcome collagen concerning Cytokines difference disease severity elderly exacerbate feature fibrosis follicular helper T cell IgG3 immature immune immune characteristics immunological change individuals Infection Inflammation less lung macrophages monocyte mononuclear cells Patient patients percentage Peripheral blood plasma plasmablasts pro-inflammatory cytokines pro-inflammatory monocytes promote proportion reduced reported risk factor SARS-CoV-2 severe COVID-19 Severe COVID-19 pneumonia severe SARS-CoV-2 specific antibody subject T cell T cells Transcriptome transcriptomic profile [DOI] 10.1038/s42003-022-03537-z PMC 바로가기 [Article Type] Article
First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine Research Published on 2022-04-192022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Amino acid anti-viral response Asymptomatic Bacterial cellular coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile dendritic cell disease Donor effective Efficacy effort elicit elicited epitope experiment Health Human humoral immune responses immune response Immunity in vivo indicated introduced negative control NTD NTD domain pathogen peptide peptide-based vaccine performed positive control predominant Protein provided Receptor binding domain Research SARS-CoV-2 SARS-CoV-2 vaccine subjects tested the Spike the vaccine Vaccine vaccine candidate Vaccines Validity volunteers [DOI] 10.1038/s41598-022-09615-w [Article Type] Research
Specific T-cell responses for guiding treatment with convalescent plasma in severe COVID-19 and humoral immunodeficiency: a case report중증 COVID-19 및 체액성 면역결핍증에서 회복기 혈장 치료를 위한 특정 T 세포 반응: 증례 보고Case Reports Published on 2022-04-112022-09-12 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] absence addition administration administration of plasma afebrile anti-viral response Anti-viral treatment antibody assessment Case report clinical decision Clinical management complex convalescent convalescent plasma Convalescent plasma therapy COVID-19 COVID-19 patient discharged elevated evidence of facilitate fatigue Genetic Hospitalized humoral humoral immune responses hyperinflammation immune response immunoglobulin replacement therapy inflammatory parameter male nasopharyngeal occur patients with COVID-19 plasma Prophylactic receiving Regular response robust SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 virus severe COVID-19 Specific Specific T-cell response suggested systemic T cell T cell response T-cell T-cell Response therapy Treatment viral clearance X-linked agammaglobulinemia XLA XLA. [DOI] 10.1186/s12879-022-07323-4 PMC 바로가기 [Article Type] Case Reports
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence회복기 동안 경증 COVID-19 외래 환자의 지속적인 항체 의존성 NK 세포 기능Immunology Published on 2022-02-072022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome addition Anti-spike anti-spike antibody anti-viral response antibody blood sample Cell characterized Cohort collected contribute convalescence coronavirus coronavirus disease correlated COVID-19 COVID-19 outpatients COVID19 defined disease Fc-effector functions female function heterogeneous humoral Humoral response identify IgA IgG titers immune correlate male natural killer neutralization NK cells activity Outpatient outpatients pandemic profile researcher response responses SARS-CoV-2 severity spike (S) glycoprotein Spike protein sustained the SARS-CoV-2 Virus neutralization while [DOI] 10.3389/fimmu.2022.796481 PMC 바로가기 [Article Type] Immunology
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses브라질 남부의 소아 COVID-19 환자는 풍부한 바이러스 mRNA와 강력한 특정 항바이러스 반응을 나타냅니다.Article Published on 2021-11-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] adult COVID-19 patient Adults anti-viral response antibodies antibody Antimicrobial responses Brazil CD8 cellular cellular immunity characterized children Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CX3CR1 dendritic dendritic cells disease Factor HLA-DR humoral immune response Immune profile immune responses infected children Infectious diseases less lymphocyte Lymphocytes mechanism mRNA N and M N and M peptide pools non-specific pediatric Pediatric patients peptide peptide pool peptide pools response SARS-CoV-2 scenario severity South structural proteins Support susceptible T cell T cell response T cells T cells response TNF Transmission Viral Viral load virus [DOI] 10.1038/s41467-021-27120-y PMC 바로가기 [Article Type] Article
Analysis of SARS-CoV-2 haplotypes and genomic sequences during 2020 in Victoria, Australia, in the context of putative deficits in innate immune deaminase anti-viral responses2020년 호주 빅토리아에서 SARS-CoV-2 일배체형 및 게놈 서열 분석Article Published on 2021-11-012022-09-11 Journal: Scandinavian journal of immunology [Category] SARS, 변종, [키워드] ADAR analysed Analysis Anti-viral anti-viral response anti-viral responses APOBEC APOBEC and ADAR deamination motifs Care cascades coronavirus vaccine COVID‐19 COVID‐19 haplotypes curated Data analysis Deamination death deficiency Department described Elderly patient elderly patients Epidemics epidemiological epidemiological data explain expression Genetic genomic sequence Government Haplotype help Human Hypothesis immune implication infected patient Infection innate immune Innate immunity interferon majority Mutagenesis occurred Patient predicted proportion response SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV-2 genome SARS-CoV-2 genomes stimulated Support tested Vaccine development Vaccine development. variant Victoria Wave [DOI] 10.1111/sji.13100 PMC 바로가기 [Article Type] Article